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Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
Published on: June 25, 2018
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Polyamines and α-Carbonic Anhydrases.
Andrea Scozzafava1, Claudiu T Supuran2, Fabrizio Carta3
1Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy. andrea.scozzafava@unifi.it.
Molecules (Basel, Switzerland)
|December 17, 2016
Summary
Natural products like polyamines are promising inhibitors of carbonic anhydrases (CAs), enzymes crucial for treating diseases like glaucoma and infections. This review explores natural and synthetic polyamines as potential CA modulators.
Area of Science:
- Biochemistry
- Medicinal Chemistry
- Pharmacology
Background:
- Natural products offer diverse chemical structures for biomedical applications.
- Carbonic anhydrases (CAs) are key targets for treating glaucoma, tumors, CNS disorders, and infectious diseases.
- Polyamines and coumarins are emerging as novel CA inhibitors.
Purpose of the Study:
- To review the current state of knowledge on natural polyamines and their synthetic derivatives.
- To highlight their potential as inhibitors of human carbonic anhydrases.
- To explore their therapeutic applications in various diseases.
Main Methods:
- Literature review of natural product chemistry and enzyme inhibition studies.
- Analysis of structure-activity relationships for polyamine-based CA inhibitors.
- Discussion of pharmacological relevance and therapeutic potential.
Main Results:
- Polyamines, both natural and synthetic, exhibit inhibitory activity against human CAs.
- These compounds represent atypical chemotypes for CA inhibition.
- Potential for developing selective CA modulators for various diseases.
Conclusions:
- Natural products, particularly polyamines, are valuable sources for novel CA inhibitors.
- Polyamines offer a promising avenue for developing new therapeutics against CA-associated pathologies.
- Further research into polyamine derivatives could yield selective and effective drugs.
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