Effiectiveness and safety of transcranial direct current stimulation in fibromyalgia: A systematic review and
Chang-E Zhu1, Bo Yu, Wen Zhang
1Shanghai First People's Hospital, Shanghai Jiao Tong University, 200080 Shanghai, China.
Objective:
To evaluate the effectiveness and safety of transcranial direct current stimulation for fibro-myalgia.
Methods:
Databases, conference records and registered trials were searched for articles published from the date of establishment of the database through to October 2015. Six randomized controlled trials (n=192) of transcranial direct current stimulation for fibromyalgia were included in the current study.
Data Extraction:
Two researchers independently screened the literature, assessed methodological quality using the Cochrane Collaboration's tool, and extracted data.
Data Synthesis:
Studies were divided into 3 groups for meta-analysis according to stimulation site and polarity. Significant improvement in pain and general fibromyalgia-related function was seen with anodal transcranial direct current stimulation over the primary motor cortex (p<0.05). However, the pressure pain threshold did not improve (p>0.05). Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex did not significantly reduce pain or improve general fibromyalgia-related function compared with sham stimulation (p>0.05). Cathodal transcranial direct current stimulation over the primary motor cortex did not improve the pressure pain threshold compared with sham stimulation (p>0.05). No significant adverse effects were seen.
Conclusion:
Anodal transcranial direct current stimulation over the primary motor cortex is more likely than sham transcranial direct current stimulation to relieve pain and improve general fibromyalgia-related function.
