Related Experiment Video
Updated: Mar 10, 2026

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
IN VITRO RELEASE KINETICS MODEL FITTING OF LIPOSOMES: AN INSIGHT
1Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences Dr. Hari Singh Gour Central University, Sagar (M.P.), 470 003, India.
Abstract:
Liposomes are emerging cargoes for bioactive delivery owing to their widely accepted biocompatible and biodegradable nature. It is always a challenge to control the release of payload for effective delivery to the site of interest. Over the couple of decennia, mathematical modeling of release process is a need of time whether the drug remains in the circulation or reaches at the target site. For establishing a better in vitro - in vivo correlation, release kinetics models viz. Peppas, Higuchi, Weibull, Zero Order and First order including mechanistic models like All-or-None, Toroidal, and Biomembrane models etc. are continuously exploited to predict drug release profile. Most of these models rely on the diffusion equations based on the composition of liposomes and conditions of release. Here, we summarized the crucial reports exploring these models and associated interventions to know the underlying physicochemical release phenomenon. Such mathematical model fitting can be a promising approach to deduce release/delivery process to help in designing the safe and efficacious ("Smart") liposomes.
More Related Videos
08:44Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
Published on: July 30, 2020
10:58SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
Published on: August 24, 2016
Related Concept Videos
In Vitro Drug Dissolution: Compendial Testing Models II
In Vitro Drug Dissolution: Compendial Testing Models I
Modified-Release Drug Delivery Systems: Bioavailability
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...