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Related Experiment Video

Updated: Mar 10, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
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Low-impedance Baseline Values Predict Severe Esophagitis.

Judith Cohen Sabban1, Gabriela D Bertoldi, Federico Ussher

  • 1*Pediatric Gastroenterology Unit †Pathology Unit, Hospital Italiano Buenos Aires, Buenos Aires. Argentina.

Journal of Pediatric Gastroenterology and Nutrition
|December 17, 2016
PubMed
Summary
This summary is machine-generated.

Esophageal baseline impedance (BI) measured by multichannel intraluminal impedance (MII) in channel 6 can accurately predict severe esophagitis in children. This non-invasive method may reduce the need for repeat upper endoscopies in pediatric patients.

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Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Physiology

Background:

  • Esophagitis diagnosis in children often relies on invasive procedures like upper endoscopy with biopsies.
  • Predictive biomarkers for severe esophageal inflammation are needed to guide clinical management.

Purpose of the Study:

  • To investigate if esophageal baseline impedance (BI) values in children can predict the presence and severity of esophagitis.
  • To assess the utility of multichannel intraluminal impedance (MII) in diagnosing pediatric esophagitis.

Main Methods:

  • Review of MII tracings and upper endoscopy/biopsy results from 87 children (3-17 years) suspected of reflux and esophagitis.
  • Exclusion of patients with eosinophilic esophagitis.
  • Analysis of mean BI in different MII channels against macroscopic and histological esophagitis scores.

Main Results:

  • Channel 6 BI <900 Ω/s showed 100% positive and negative predictive value for grade 3 or macroscopic esophagitis.
  • Children with no or mild esophagitis (biopsy score 0-2) had BI >2000 Ω/s in channel 6.
  • Histologic grade 3 esophagitis impacted esophageal epithelium integrity.

Conclusions:

  • Esophageal BI in channel 6 is a highly accurate predictor of severe esophagitis in children.
  • MII-derived BI may serve as a valuable tool for predicting severe esophageal inflammation and potentially reducing the need for repeat endoscopies.
  • Severe esophagitis can affect esophageal integrity even without visible macroscopic changes.