Autophagic targeting and avoidance in intracellular bacterial infections

Eukaryotic cells use autophagy to break down and recycle components such as aggregated proteins and damaged organelles. Research in the past decade, particularly using Salmonella enterica serovar Typhimurium as a model pathogen, has revealed that autophagy can also target invading intracellular bacterial pathogens for degradation. However, many bacterial pathogens have evolved mechanisms that allow for evasion of the autophagic pathway, such as motility or direct and irreversible cleavage of proteins that comprise the autophagic machinery. As a complete and detailed understanding of the autophagic pathway and its derivatives continues to develop, it is likely that other mechanisms of inhibition by bacterial pathogens will be discovered.