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Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue
Thomas Birngruber1, Frank Sinner2
1Joanneum Research GmbH, HEALTH - Institute for Biomedicine and Health Sciences, Neue Stiftingtalstrasse 2, 8010 Graz, Austria.
Drug Discovery Today. Technologies
|December 18, 2016
Summary
Cerebral open flow microperfusion (cOFM) enables continuous brain fluid sampling for drug development. This in-vivo technique monitors blood-brain barrier transport and tissue metabolism, aiding pharmaceutical research.
Area of Science:
- Neuroscience
- Pharmacology
- Biomedical Engineering
Background:
- Cerebral open flow microperfusion (cOFM) is an emerging in-vivo technique.
- It allows for continuous sampling of interstitial fluid within brain tissue.
Purpose of the Study:
- To introduce and highlight the capabilities of cOFM.
- To demonstrate its utility in pharmacokinetic and pharmacodynamic studies.
- To emphasize its potential in developing brain-relevant pharmaceuticals.
Main Methods:
- In-vivo implantation of cOFM devices into brain tissue.
- Continuous monitoring of interstitial fluid composition.
- Application of drugs to assess transport and metabolic changes.
Main Results:
- cOFM facilitates real-time monitoring of substance transport across the blood-brain barrier.
- The technique allows for the investigation of drug-induced metabolic alterations in brain tissue.
- Successful long-term implantation demonstrates feasibility for extended studies.
Conclusions:
- Cerebral open flow microperfusion is a valuable tool for in-vivo brain research.
- It offers significant advantages for pharmacokinetic and pharmacodynamic assessments.
- cOFM holds great promise for accelerating the development of central nervous system drugs.
