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Infective endocarditis in patients with oncological diseases
Cristina Mesa Del Castillo-Payá1, Marcos Rodríguez-Esteban2, Alejandro Quijada-Fumero2
1Servicio de Oncología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España.
Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)
|December 18, 2016
Summary
Cancer patients face a higher risk of infective endocarditis (IE), often linked to healthcare. This condition in cancer patients presents with high mortality and limited treatment options.
Area of Science:
- Infectious Diseases
- Oncology
- Cardiology
Background:
- Cancer patients are a special risk group for infective endocarditis (IE) due to frequent invasive procedures.
- Understanding the unique clinical profile and prognosis of IE in cancer patients is crucial.
Purpose of the Study:
- To determine the differential clinical profile of infective endocarditis (IE) in cancer patients.
- To compare the prognosis of IE in patients with and without cancer.
Main Methods:
- A retrospective observational study of 208 IE cases between 2005 and 2015.
- Comparative analysis between IE patients with and without cancer, including long-term follow-up.
Main Results:
- IE in cancer patients was primarily healthcare-associated (59.5%) and frequently caused by Staphylococcus aureus (35%).
- Tricuspid valve involvement was three times more common in cancer patients (18.8%).
- Cancer patients had significantly higher in-hospital mortality (45.5%) and lower one-year survival (40%).
Conclusions:
- Infective endocarditis in cancer patients is often staphylococcal, associated with healthcare, and carries a high early mortality.
- Therapeutic limitations exist for IE in cancer patients, despite indications for intervention.
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