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The 'well control' artefact in case/control studies of specific psychiatric disorders
1New York State Psychiatric Institute, Columbia University.
Psychological Medicine
|August 1, 1989
Abstract:
An appropriate choice of controls in case/control studies of specific psychiatric disorders is crucial for valid risk-factor assessment. One suggested approach to control-group selection, the use of a well control group, is the focus of this paper. While using well controls has intuitive appeal, this paper shows that such a procedure can lead to ambiguous and biased results.