Related Experiment Video
Updated: Jan 3, 2026
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
Aldehyde-functionalized dendritic mesoporous silica nanoparticles as potential nanocarriers for pH-responsive protein
Zhengfang Tian1, Yi Xu2, Yufang Zhu3
1Hubei Key Laboratory of Processing and Application of Catalytic Materials, College of Chemical Engineering, Huanggang Normal University, Huanggang 438000, China.
Abstract:
We developed a potential pH-responsive protein drug delivery system based on aldehyde-functionalized dendritic mesoporous silica nanoparticles (DMSNs-CHO) as nanocarriers. The structure, protein drug loading and release behavior, in vitro cytotoxicity and cell uptake of the DMSNs-CHO nanoparticles were investigated. The results showed that the uniform DMSNs-CHO nanoparticles had an average particle size of 174±17nm and a mesopore size of 7.7nm. Using bovine serum albumin (BSA) as a model protein drug, BSA could be loaded into DMSNs-CHO nanoparticles owing to the formation of imine bonds between aldehyde groups and primary amines of BSA molecules. BSA loading capacity was about 136μg/mg, and BSA release from DMSNs-CHO nanocarriers was dependent on pH environment. Furthermore, the DMSNs-CHO nanoparticles had no cytotoxicity and could be efficiently taken up by cells. Therefore, the DMSNs-CHO nanoparticles would be promising as nanocarriers for pH-responsive delivery of protein drugs.
