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Role of nanostructured aggregation of chitosan derivatives on [5-methionine]enkephalin affinity
Federica Aiello1, Federica Balzano1, Luca Carpita1
1Università di Pisa, Dipartimento di Chimica e Chimica Industriale, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.
Carbohydrate Polymers
|December 19, 2016
Abstract:
Affinities of quaternary ammonium-chitosan conjugates, their thiolated derivatives and corresponding nanostructured aggregates towards the hydrophilic drug [5-methionine]enkephalin were compared by Nuclear Magnetic Resonance (NMR) spectroscopic methods based on proton selective relaxation rate measurements. Nanoaggregates showed enhanced drug affinity in comparison with corresponding polymers, especially in the case of thiolated systems.

