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A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
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Single-Dose Dalbavancin: A Review in Acute Bacterial Skin and Skin Structure Infections

Karly P Garnock-Jones1

  • 1Springer, Private Bag 65901, Mairangi Bay 0754, Auckland, New Zealand. demail@springer.com.

Drugs
|December 19, 2016
PubMed

Insights

Single-dose dalbavancin effectively treats acute bacterial skin infections in adults, showing comparable efficacy and tolerability to the two-dose regimen. This offers a convenient and promising alternative for ABSSSI treatment.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Dermatology

Background:

  • Dalbavancin, an intravenous lipoglycopeptide antibiotic, was initially approved for acute bacterial skin and skin structure infections (ABSSSI) using a two-dose regimen.
  • Recent approvals now include a single-dose regimen for ABSSSI treatment in adult patients.

Purpose of the Study:

  • To review the pharmacological properties of intravenous dalbavancin.
  • To evaluate the clinical efficacy and tolerability of the single-dose dalbavancin regimen for ABSSSI in adults.

Main Methods:

  • This study is a narrative review of existing literature.
  • It focuses on pharmacological data, clinical trial results, and adverse event profiles of single-dose dalbavancin for ABSSSI.

Main Results:

  • Single-dose dalbavancin demonstrated non-inferior early clinical response compared to the two-dose regimen.
  • Clinical success rates at 14 and 28 days were similar between the single- and two-dose regimens, regardless of baseline pathogen.
  • The single-dose regimen was generally well-tolerated with low adverse event rates.

Conclusions:

  • Single-dose dalbavancin is an effective and well-tolerated option for treating adult ABSSSI.
  • Its favorable pharmacokinetic profile supports convenient single-dose administration.
  • Dalbavancin presents a valuable alternative to conventional antibiotics for ABSSSI.

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