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Detecting Positive Selection of Korean Native Goat Populations Using Next-Generation Sequencing
Wonseok Lee1, Sojin Ahn2, Mengistie Taye1,3
1Department of Agricultural Biotechnology, Animal Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.
Molecules and Cells
|December 19, 2016
Summary
Native Korean goats, known for lumbar paralysis resistance, show distinct genetic features. Genome analysis identified the CCR3 gene as a key factor in their unique adaptations.
Area of Science:
- Animal Genetics
- Comparative Genomics
- Livestock Science
Background:
- Native Korean goats (Capra hircus) are an ancient domestic breed with unique traits, including resistance to lumbar paralysis.
- Despite small body size and low production, their genetic distinctiveness and adaptive traits warrant investigation.
Purpose of the Study:
- To identify distinct genetic features and selection patterns in native Korean goats.
- To compare the genomes of native Korean goats with crossbred populations.
Main Methods:
- Whole-genome sequencing of 15 native Korean goats and 11 crossbred goats using the Illumina platform.
- Analysis of nucleotide diversity and genetic structure between populations.
- Identification of selective sweep regions using cross-population extended haplotype homozygosity (XP-EHH) and cross-population composite likelihood ratio test (XP-CLR).
Main Results:
- Native Korean goats exhibit decreased nucleotide diversity compared to crossbred goats.
- Genetic structural analysis confirms distinct populations with a shared ancestry.
- Candidate genes for recent selection, including CCR3 associated with lumbar paralysis resistance, were identified.
Conclusions:
- The study reveals unique genetic characteristics and selection patterns in native Korean goats.
- The CCR3 gene is a potential genetic marker for lumbar paralysis resistance in this breed.
- Findings contribute to a deeper understanding of native Korean goat genome and conservation efforts.
