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A Purinergic Trail for Metastases.

Davide Ferrari1, Fabio Malavasi2, Luca Antonioli3

  • 1Department of Life Science and Biotechnology, University of Ferrara, Ferrara, Italy.

Trends in Pharmacological Sciences
|December 20, 2016
PubMed
Summary

Nucleotides and nucleosides promote cancer spread by aiding tumor cell migration and tissue colonization. Targeting purinergic signaling offers a new strategy for developing antimetastatic therapies.

Keywords:
P1 receptorsP2 receptorschemotaxisextracellular nucleotidestumor

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Nucleotides and nucleosides are key regulators of biological processes.
  • Emerging evidence highlights their role in tumor progression.

Purpose of the Study:

  • To review the prometastatic roles of nucleotides and nucleosides.
  • To explore the potential of purinergic signaling modulation in cancer therapy.

Main Methods:

  • Literature review of recent studies on nucleotides, nucleosides, and cancer metastasis.
  • Analysis of purinergic signaling pathways involved in tumor cell migration and colonization.

Main Results:

  • Nucleotides and nucleosides released by tumors act as potent prometastatic factors.
  • These molecules enhance tumor cell migration and facilitate tissue colonization.

Conclusions:

  • Nucleotides and nucleosides represent a novel class of prometastatic factors.
  • Modulating purinergic signaling holds promise for future antimetastatic treatments.