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[Systemic cardiorespiratory effects induced by doxofylline].

G F Bagnato, A Allegra, A De Leo

    Rivista Europea Per Le Scienze Mediche E Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Europeenne Pour Les Sciences Medicales Et Pharmacologiques
    |February 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

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    Doxofylline demonstrates equal therapeutic efficacy to theophylline for treating obstructive lung disease, offering improved clinical tolerability. This new methyl-xanthinic derivative is effective for bronchostructive disorders.

    Area of Science:

    • Pharmacology
    • Respiratory Medicine

    Context:

    • Chronic obstructive lung disease (COPD) management requires effective bronchodilators.
    • Methyl-xanthinic derivatives are commonly used for respiratory conditions.

    Purpose:

    • To evaluate the clinical effectiveness and tolerability of doxofylline compared to theophylline in COPD patients.
    • To assess the pharmacokinetic and pharmacodynamic properties of doxofylline.

    Summary:

    • A randomized study compared intravenous doxofylline (200 mg) and theophylline (240 mg) in 13 COPD patients.
    • Arterial blood gases, FEV1, and ECG were monitored post-infusion.
    • Doxofylline showed comparable therapeutic efficacy to theophylline but with significantly better clinical tolerability.

    Impact:

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    • Doxofylline presents a viable alternative for treating bronchostructive disorders.
    • The findings support doxofylline's potential as a safer bronchodilator option.