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Related Experiment Video

Updated: Mar 9, 2026

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
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Plasma free reversible and irreversible microfluidic bonding.

M Chu1, T T Nguyen2, E K Lee1

  • 1Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA. mkhine@uci.edu.

Lab on a Chip
|December 20, 2016
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Summary

We developed an easy, plasma-free method to create sealed microfluidic chips using a PDMS adhesive. This versatile technique simplifies multilayer device fabrication and protein micropatterning, making microfluidics accessible for education.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Chemical Engineering

Background:

  • Microfluidic devices are crucial for various applications, including cell culture and diagnostics.
  • Current fabrication methods often require specialized equipment like plasma treatment, limiting accessibility.
  • Developing simpler, cost-effective fabrication techniques is essential for broader adoption.

Purpose of the Study:

  • To present a facile, plasma-free method for fabricating sealed microfluidic chips.
  • To demonstrate the versatility of the method for both reversible and irreversible sealing.
  • To enable accessible microfluidic device fabrication, particularly for educational settings.

Main Methods:

  • Utilized a polydimethylsiloxane (PDMS)-based adhesive polymer mixture for chip fabrication.
  • Employed a plasma-free sealing process compatible with existing PDMS microfluidics workflows.
  • Integrated the method with Shrinky-Dink microfluidic prototyping for capital-equipment-free fabrication.

Main Results:

  • Successfully fabricated both reversibly and irreversibly sealed microfluidic chips.
  • Demonstrated compatibility with standard PDMS microfluidics processes.
  • Showcased suitability for multilayer device fabrication and protein micropatterning for cell culturing.

Conclusions:

  • The developed method offers a versatile and accessible approach to microfluidic chip fabrication.
  • Eliminating the need for plasma treatment and capital equipment significantly lowers the barrier to entry.
  • This technique holds promise for advancing microfluidics research and education.