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Related Concept Videos

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Icariin-treated human umbilical cord mesenchymal stem cells decrease chronic liver injury in mice.

Huantian Cui1, Zhen Liu2, Li Wang3

  • 1Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

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|December 20, 2016
PubMed
Summary

Icariin (ICA) enhances human umbilical cord mesenchymal stem cells (hUMSCs) to improve liver function and reduce fibrosis in chronic liver injury models. ICA treatment promotes hUMSC migration to injured liver tissue.

Keywords:
Carbon tetrachlorideHuman umbilical cord mesenchymal stem cellsIcariinLiver injury

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Hepatology

Background:

  • Human umbilical cord mesenchymal stem cells (hUMSCs) possess differentiation potential but limited migration to damaged tissues.
  • Traditional Chinese Medicine concepts suggest kidney-tonifying herbs may enhance stem cell migration and differentiation.
  • Previous research indicated icariin (ICA) upregulates hUMSC pluripotency genes and promotes migration in kidney injury models.

Purpose of the Study:

  • To evaluate the therapeutic effects of ICA-treated hUMSCs in a carbon tetrachloride (CCl4)-induced chronic liver injury (CLI) mouse model.
  • To investigate ICA's role in promoting hUMSC migration and engraftment within injured liver tissue.
  • To assess the impact of ICA-treated hUMSCs on liver function, oxidative stress, and hepatic fibrosis.

Main Methods:

  • Chronic liver injury was induced in mice using intraperitoneal injections of CCl4.
  • ICA-treated hUMSCs were administered to the CLI mice via intravenous injection.
  • Outcomes were assessed through survival rates, serum biochemistry, liver pathology, and measurement of antioxidant activity and fibrosis markers.

Main Results:

  • ICA-treated hUMSCs significantly accelerated liver function recovery in mice with CCl4-induced CLI.
  • Treatment with ICA-treated hUMSCs enhanced antioxidant activity in the liver and mitigated the progression of hepatic fibrosis.
  • Icariin effectively induced the migration of transplanted hUMSCs to the injured liver tissues.

Conclusions:

  • Icariin-treated hUMSCs demonstrate significant recovery and protective effects in a mouse model of CCl4-induced chronic liver injury.
  • ICA enhances the therapeutic potential of hUMSCs by promoting their migration to sites of liver injury.
  • These findings support the potential of ICA-modified stem cells for treating chronic liver diseases.