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Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

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Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
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2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
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A specific brushing sequence and plaque removal efficacy: a randomized split-mouth design.

E Van der Sluijs1, D E Slot1, N L Hennequin-Hoenderdos1

  • 1Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

International Journal of Dental Hygiene
|December 20, 2016
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Summary
This summary is machine-generated.

Starting toothbrushing on the lingual or buccal aspect of teeth yields similar plaque reduction. This study found no significant difference in plaque removal effectiveness, challenging the common recommendation to begin with the lingual surfaces.

Keywords:
brushing orderdental plaquemanual toothbrushsequence

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Area of Science:

  • Dentistry
  • Oral Hygiene Research

Background:

  • Dental professionals often recommend starting toothbrushing on the lingual (tongue-side) surfaces, assuming they are harder to clean.
  • Evidence supporting this specific brushing order is limited.

Purpose of the Study:

  • To investigate whether starting toothbrushing on the lingual aspect of teeth is more effective for plaque removal compared to starting on the buccal (cheek-side) aspect.

Main Methods:

  • A randomized controlled clinical trial with a split-mouth design was conducted on 46 students.
  • Participants refrained from oral hygiene for 48 hours prior to assessment.
  • Plaque Index (PI) scores were recorded before and after brushing, with quadrants assigned to start lingually or buccally.

Main Results:

  • No significant difference in plaque reduction was observed between starting on the lingual (55% reduction) versus the buccal (58% reduction) aspect.
  • The mean difference in plaque scores between the two brushing orders was not statistically significant (P = 0.219).
  • Subanalyses of buccal, lingual, and approximal surfaces also showed no significant differences based on brushing order.

Conclusions:

  • Manual toothbrushing effectively reduces plaque scores regardless of whether the lingual or buccal aspect is brushed first.
  • The study's findings do not support the recommendation to prioritize lingual surfaces for initial toothbrushing in this young adult population.