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Updated: Mar 9, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Positive variation of the MRI signal via intramolecular inclusion complexation of a C-2 functionalized β-cyclodextrin
I Zgani1, H Idriss2, C Barbot1
1Normandie Univ, COBRA, UMR 6014, FR 3038, INSA Rouen, CNRS, IRIB IRCOF 1 rue Tesnière, 76821 Mont-Saint-Aignan, France. geraldine.gouhier@univ-rouen.fr.
Abstract:
The synthesis of a new contrast agent based on a β-cyclodextrin scaffold and bearing a flexible lipophilic spacer arm on its secondary face is reported. Intermolecular host-guest inclusion complexes were known to undergo an enhancement of the contrast imaging. We extend this concept to intramolecular complexation. Inter- and intramolecular interactions are compared by NMR spectroscopy, circular dichroism and magnetic resonance imaging using hydrocinnamic acid and adamantane carboxylic acid as external guests. This positive variation of the observed relaxivity is a key element of new strategies aiming at developing smart molecular MRI probes.
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