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Neuropsychiatric Lupus in clinical practice
Helena Alessi1, Lívia Almeida Dutra1, Pedro Braga2,3
1Universidade Federal de São Paulo, Divisão de Neurologia Geral, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
Arquivos De Neuro-Psiquiatria
|December 20, 2016
Summary
Systemic lupus erythematosus (SLE) can affect the nervous system in up to 50% of patients, leading to significant health issues. This review covers key neurological symptoms, diagnosis, and treatments for SLE patients.
Area of Science:
- Immunology
- Neurology
- Rheumatology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs.
- Autoantibodies and tissue injury characterize SLE.
- Genetic and environmental factors contribute to SLE etiology.
Purpose of the Study:
- To review the major neuropsychiatric manifestations in patients with SLE.
- To discuss clinical features, radiological findings, and treatment options for these manifestations.
Main Methods:
- Literature review of neuropsychiatric syndromes associated with SLE.
- Categorization of manifestations into central and peripheral nervous system involvement.
Main Results:
- Neurological involvement affects up to 50% of SLE patients.
- Nineteen distinct neuropsychiatric syndromes have been identified in SLE.
- Neurological manifestations significantly impact quality of life and increase morbidity/mortality.
Conclusions:
- Neuropsychiatric involvement is a common and serious complication of SLE.
- Comprehensive understanding of clinical, radiological, and therapeutic aspects is crucial for patient management.
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