Related Experiment Video
Updated: Mar 9, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Spontaneous intracranial epidural hematoma during rivaroxaban treatment
Leonardo Gilmone Ruschel1, Felipe Marques Monteiro do Rego1, Jerônimo Buzetti Milano2
1MD, Resident of the Neurosurgery Residency Program at Instituto de Neurologia de Curitiba (INC), Curitiba, PR, Brazil.
Abstract:
According to our research, this is the first case described in the literature of spontaneous intracranial epidural hematoma secondary to the use of Xareltor. Spontaneous intracranial epidural hematomas are rarely described in the literature. They are associated with infectious diseases of the skull, coagulation disorders, vascular malformations of the dura mater and metastasis to the skull. Long-term post-marketing monitoring and independent reports will probably detect the full spectrum of hemorrhagic complications of the use of rivaroxaban.
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