Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

3.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.0K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.5K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

711
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
711
Abnormal Proliferation02:23

Abnormal Proliferation

5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

575
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
575
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

848
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
848

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pregnancy outcomes in women with idiopathic inflammatory myopathies: a single-centre study from Sweden.

Scandinavian journal of rheumatology·2026
Same author

Evaluation of additional resources and stories within therapist-assisted internet-delivered cognitive behaviour therapy for alcohol misuse.

Internet interventions·2025
Same author

Gene expression and copy number profiling of follicular lymphoma biopsies from patients treated with first-line rituximab without chemotherapy.

Leukemia & lymphoma·2023
Same author

The BioLymph study - implementing precision medicine approaches in lymphoma diagnostics, treatment and follow-up: feasibility and first results.

Acta oncologica (Stockholm, Sweden)·2023
Same author

Effects on hemodynamic enhancement and discomfort of a new textile electrode integrated in a sock during calf neuromuscular electrical stimulation.

European journal of applied physiology·2023
Same author

Validity of clinical psoriatic arthritis diagnoses made by rheumatologists in the Swedish National Patient Register.

Scandinavian journal of rheumatology·2022

Related Experiment Video

Updated: Mar 9, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

1.2K

Rheumatoid Arthritis and Risk of Malignant Lymphoma: Is the Risk Still Increased?

K Hellgren1, E Baecklund2, C Backlin2

  • 1Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.

Arthritis & Rheumatology (Hoboken, N.J.)
|December 20, 2016
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis (RA) patients still face an increased lymphoma risk, similar to historical data. Standard RA treatments like methotrexate and TNF inhibitors do not appear to elevate this risk, but oral corticosteroids may reduce it.

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

Related Experiment Videos

Last Updated: Mar 9, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

1.2K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

Area of Science:

  • Rheumatology
  • Oncology
  • Epidemiology

Background:

  • Patients with rheumatoid arthritis (RA) have a known increased risk of malignant lymphomas.
  • RA disease severity is strongly correlated with lymphoma risk.
  • Changes in RA therapy over recent decades necessitate re-evaluation of lymphoma risk.

Purpose of the Study:

  • To assess if lymphoma risk remains elevated in RA patients.
  • To identify predictors of lymphoma risk in RA.
  • To explore the subtypes of lymphoma occurring in RA patients.

Main Methods:

  • 12,656 incident RA cases from the Swedish Rheumatology Quality Register (1997-2012) were analyzed.
  • RA therapy and inflammatory activity in the first year post-diagnosis were recorded.
  • Lymphoma diagnoses, including subtypes, were identified via linkage to the Swedish Cancer Register and compared to 10 matched population controls per patient using Cox regression.

Main Results:

  • An increased overall hazard ratio (HR) for lymphoma in RA patients was observed (HR 1.6, 95% CI 1.2-2.1).
  • Lymphoma risk did not decline over successive calendar years of RA diagnosis.
  • Neither methotrexate nor tumor necrosis factor inhibitors (TNFi) increased lymphoma risk (HR 0.9), while oral corticosteroids were associated with reduced risk (HR 0.5).
  • First-year inflammatory activity did not predict lymphoma risk.
  • Chronic lymphocytic leukemia was less frequent, and Hodgkin's lymphoma more frequent in RA patients compared to the general population.

Conclusions:

  • The lymphoma risk in recently diagnosed RA patients is comparable to historical cohorts.
  • Standard antirheumatic treatments, including TNFi, do not predict future lymphoma risk.
  • The observed distribution of lymphoma subtypes in RA warrants further investigation.