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Light-driven Enzymatic Decarboxylation
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Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges?
Yonghua Wang1, Dongming Lan1, Rabia Durrani2
1School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Abstract:
Peroxygenases are promising catalysts for preparative oxyfunctionalization chemistry as they combine the versatility of P450 monooxygenases with simplicity of cofactor-independent enzymes. Though many interesting applications have been reported, today 'we have only scratched the surface' and significant efforts are necessary to solve issues related to selectivity of the wild type enzymes and low product titers. For this, further elucidation of the vast natural diversity as well as protein and reaction engineering approaches are discussed.
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