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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

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Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
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Coronary Artery Disease V: Interprofessional Care01:27

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Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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Related Experiment Video

Updated: Mar 9, 2026

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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New Drugs for Atherosclerosis.

Caroline S Bruikman1, Robert M Stoekenbroek1, G Kees Hovingh1

  • 1Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

The Canadian Journal of Cardiology
|December 21, 2016
PubMed
Summary
This summary is machine-generated.

Atherosclerosis, a key factor in cardiovascular disease (CVD), is linked to dyslipidemia. Novel lipid-lowering therapies beyond statins are emerging to combat persistent CVD mortality.

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Atherosclerosis is a primary driver of clinical cardiovascular disease (CVD).
  • Dyslipidemia is a critical risk factor in the development of atherosclerosis.
  • Statins effectively reduce low-density lipoprotein cholesterol (LDL-C) and CVD events, but CVD remains a leading cause of mortality.

Purpose of the Study:

  • To review novel therapeutic agents for lipid lowering.
  • To explore potential advancements in anti-atherosclerotic drug therapy.

Main Methods:

  • Review of current and emerging lipid-lowering drug development.
  • Analysis of the role of dyslipidemia in atherosclerosis progression.

Main Results:

  • Despite statin therapy, significant residual CVD risk persists.
  • Several novel lipid-lowering agents are progressing through development pipelines.

Conclusions:

  • Novel therapeutic agents hold promise for revolutionizing anti-atherosclerotic drug therapy.
  • Addressing residual risk through new therapies is crucial for reducing CVD mortality.