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Encapsulating darunavir nanocrystals within Eudragit L100 using coaxial electrospraying.
Duong Nhat Nguyen1, Christian Clasen2, Guy Van den Mooter1
1KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, Leuven B-300, Belgium.
Summary
Coaxial electrospraying successfully created drug nanocrystals within a polymer shell, achieving high encapsulation efficiency. This technique offers a promising method for developing advanced drug delivery systems.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Nanotechnology
Background:
- Electrospraying is a versatile technique for producing nano/microscale particles.
- Controlling particle characteristics like size and morphology is crucial for drug delivery.
Purpose of the Study:
- To investigate coaxial electrospraying for preparing drug nanocrystals encapsulated in a polymer shell.
- To evaluate the feasibility of this method for drug delivery applications.
Main Methods:
- Aqueous nanosuspensions of darunavir were prepared using wet media milling.
- Coaxial electrospraying utilized darunavir nanosuspension (core) and Eudragit L100 polymer solution (shell).
- Particle characteristics and in vitro drug release were analyzed.
Main Results:
- Coaxial electrospraying produced core-shell nanoparticles with high darunavir encapsulation efficiency (~90%).
- Particle characteristics were influenced by nanosuspension properties and flow rates.
- The enteric coating significantly reduced drug release in acidic conditions (to ~20%).
Conclusions:
- Coaxial electrospraying is a viable technique for encapsulating drug nanocrystals within a polymeric shell.
- This method shows potential for developing controlled-release drug formulations.
