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Area of Science:

  • Pediatric Intensive Care
  • Extracorporeal Procedures
  • Therapeutic Apheresis

Background:

  • Therapeutic plasma exchange (TPE) is an extracorporeal procedure used to remove harmful plasma components or blood cells.
  • This study focuses on the implementation of TPE in a pediatric intensive care setting.

Purpose of the Study:

  • To present the results of therapeutic plasma exchange (TPE) implementation in children.
  • To evaluate the outcomes and complications of TPE in a pediatric intensive care unit.

Main Methods:

  • The study analyzed 66 TPE procedures performed on 11 pediatric patients between December 2011 and June 2016.
  • Data collected included patient demographics, underlying diseases, concurrent treatments, and complications.

Main Results:

  • The average patient age was 11.6 years, with a higher incidence in girls.
  • Neurological conditions were the most common underlying diseases (54.5%).
  • Hypotension (45.5%), bleeding (36.3%), hypercoagulability (27.2%), and hematoma (27.2%) were the most frequent complications. Three patients (27.2%) experienced a lethal outcome.

Conclusions:

  • TPE is an invasive procedure requiring central venous catheterization, carrying risks such as hypotension and bleeding.
  • Successful TPE in children necessitates a multidisciplinary team including pediatric nephrologists, neurologists, and intensive care specialists.
  • A well-trained medical and nursing staff is essential for managing TPE procedures and potential complications effectively.