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Risk factors for early invasive fungal disease in critically ill patients

Gurmeet Singh1, Ceva Wicaksono Pitoyo1, Dita Aditianingsih2

  • 1Department of Internal Medicine, Respirology and Critical Illness Division, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|December 21, 2016
PubMed
Abstract

Insights

Diabetes mellitus (DM) is a significant risk factor for early invasive fungal disease (IFD) in critically ill patients. Early detection and management of DM can help reduce IFD incidence and improve outcomes in this vulnerable population.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Invasive fungal disease (IFD) incidence is rising globally, particularly in critically ill patients.
  • Early detection and treatment are crucial for reducing morbidity and mortality in intensive care units (ICUs).

Purpose of the Study:

  • To identify factors associated with early IFD in critically ill patients.

Main Methods:

  • Prospective cohort study of critically ill patients from March to September 2015.
  • Specimens collected on days 5-7 of hospitalization.
  • Multivariate logistic regression analysis performed on factors with P < 0.25 in bivariate analysis.

Main Results:

  • 206 patients enrolled; 74 had IFD. Candida sp. was the most common isolate (92.2%).
  • Urine culture most frequently yielded fungal isolates (70.1%).
  • Diabetes mellitus (DM) was an independent factor associated with early IFD (OR 2.078, P=0.018).

Conclusions:

  • DM is a significant risk factor for early IFD in critically ill patients.
  • Targeting DM management may reduce IFD incidence in ICUs.
Keywords:
Candidacritically illdiabetes mellitusearly invasive fungal diseaserisk factor

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