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Updated: Mar 9, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

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The Antibiotic Drug Tigecycline: A Focus on its Promising Anticancer Properties

Zhijie Xu1, Yuanliang Yan2, Zhi Li3

  • 1Department of Pathology, Xiangya Hospital, Central South UniversityChangsha, China; Department of Pathology, School of Basic Medicine, Central South UniversityChangsha, China.

Frontiers in Pharmacology
|December 21, 2016
PubMed

Insights

Tigecycline, an antibiotic, shows promising anti-tumor effects by impacting cancer cell signaling and mitochondria. This review details its efficacy and side effects across various cancers, guiding future clinical trials.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Tigecycline (TIG), a glycylcycline antibiotic, is approved for complicated infections.
  • Emerging research highlights TIG's potential anti-tumor properties.

Approach:

  • This review synthesizes existing evidence on TIG's anti-cancer activity.
  • It examines TIG's effects on signaling pathways and mitochondrial function in cancer cells.
  • The review covers TIG's efficacy and side effects in various cancer types, including AML, glioma, and NSCLC.

Key Points:

  • TIG demonstrates inhibitory effects on cancer cells.
  • Its anti-tumor action is linked to modulation of signaling pathways and mitochondrial function.
  • Evidence supports TIG's activity against acute myeloid leukemia, glioma, and non-small cell lung cancer.

Conclusions:

  • TIG exhibits significant anti-tumor potential across diverse cancer types.
  • Further clinical trials are warranted to confirm its safety and efficacy in cancer treatment.
  • Understanding TIG's mechanisms of action can optimize its therapeutic application in oncology.
Keywords:
Akt signalinganti-cancer effectsclinical trialsmitochondrial functionside effectstigecycline

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