Preliminary Experience Using Full-Spectrum Endoscopy for Colorectal Cancer Screening: Matched Case Controlled Study.

Area of Science:

• Gastroenterology
• Endoscopy
• Colorectal Cancer Screening

Background:

• High-quality colonoscopy is crucial for reducing colorectal cancer morbidity and mortality.
• Full-spectrum endoscopy (FUSE) has emerged as a technology with potential to enhance adenoma detection during colonoscopy.

Purpose of the Study:

• To evaluate the feasibility and clinical utility of FUSE colonoscopy.
• To compare FUSE colonoscopy with standard colonoscopy (SC) in terms of key performance metrics.

Main Methods:

• A prospective study involving 130 patients undergoing FUSE colonoscopy for screening.
• Comparison of cecal intubation rate (CIR), procedure time, polyp/adenoma detection rate (PDR/ADR), and adenomas per colonoscopy (APC) with 260 matched-control patients who underwent SC.
• Subjective evaluation of FUSE utility by endoscopists via questionnaires.

Main Results:

• FUSE colonoscopy achieved a high CIR of 94.6%.
• Procedure times for FUSE were significantly longer than SC (cecal intubation: 8.8 min vs. 5.1 min; total procedure: 21.6 min vs. 17.3 min).
• No significant differences were observed in PDR, ADR, or APC between FUSE and SC groups.

Conclusions:

• FUSE colonoscopy did not demonstrate superiority over standard colonoscopy in a clinical screening setting.
• Despite a wider field of view, FUSE did not yield improved adenoma detection rates.