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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Liver Regeneration01:24

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine
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Cellular Transplantation for Liver Diseases.

Elizabeth Jameson1

  • 1Department of Medicine, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada, H3G 1Y6.

Gastroenterology Research
|December 21, 2016
PubMed
Summary

Orthotropic liver transplantation (OLT) faces donor shortages. Stem cell transplantation offers a promising, less invasive alternative for liver disease treatment, with potential for future clinical use.

Keywords:
cell transplantationliver failureorthotropic liver transplantationstem cells

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Area of Science:

  • Hepatology and Regenerative Medicine
  • Cellular Therapeutics

Background:

  • Orthotropic liver transplantation (OLT) is the primary treatment for hepatic failure but is limited by donor organ scarcity.
  • Alternative strategies are needed to restore liver function due to the limited success of OLT.

Conclusions:

  • Cellular therapy, particularly using stem cells, shows significant promise as an alternative to OLT for treating liver diseases.
  • While currently experimental, cell-based therapies are anticipated to become effective clinical options in the near future.