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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target

Isaac E Marx1, Thomas A Dineen1, Jessica Able1

  • 1Department of Medicinal Chemistry, Department of Molecular Engineering, Department of Pharmacokinetics and Drug Metabolism, Department of Neuroscience, and Department of Biologics, Amgen, Inc. , 360 Binney Street, Cambridge, Massachusetts 02142, and One Amgen Center Drive, Thousand Oaks, California 91320, United States.

ACS Medicinal Chemistry Letters
|December 21, 2016
PubMed

Keywords:
NaV1.5NaV1.7Sodium channelhistamine scratching modelpain

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