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Bone Union Rate Following Instrumented Posterolateral Lumbar Fusion: Comparison between Demineralized Bone Matrix
1Department of Orthopaedic Surgery, Kangwon National University College of Medicine, Chuncheon, Korea.
Study Design:
Retrospective study.
Purpose:
To compare the union rate of posterolateral lumbar fusion (PLF) using demineralized bone matrix (DBM) versus hydroxyapatite (HA) as bone graft extender.
Overview Of Literature:
To our knowledge, there has been no clinical trial to compare the outcomes of DBM versus HA as a graft material for PLF.
Methods:
We analyzed prospectively collected data from consecutive 79 patients who underwent instrumented PLF. Patients who received DBM were assigned to group B (n=38), and patients who received HA were assigned into group C (n=41). The primary study outcome was fusion rate assessed with radiographs. The secondary outcomes included pain intensity using a visual analogue scale, functional outcome using Oswestry disability index score, laboratory tests of inflammatory profiles and infection rate.
Results:
One year postoperatively, bone fusion was achieved in 73% in group B and 58% in group C without significant difference between the groups (p=0.15). There were no differences between the groups with respect to secondary outcomes.
Conclusions:
DBM would provide noninferior outcomes compared to the HA as a fusion material for PLF, and could be a notable alternative.
