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Updated: Mar 9, 2026

Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy
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Surgery and Hepatocellular Carcinoma.

Nobuhisa Akamatsu1, Umberto Cillo2, Alessandro Cucchetti3

  • 1Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Organ Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Liver Cancer
|December 21, 2016
PubMed
Summary

Optimizing surgical strategies for hepatocellular carcinoma (HCC) requires better assessment of liver function and remnant volume. Current algorithms are flawed, leading to disparities in treatment recommendations between Eastern and Western countries.

Keywords:
Hepatocellular carcinomaLiver resectionLiver transplantation

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Last Updated: Mar 9, 2026

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Area of Science:

  • Hepatobiliary Surgery
  • Surgical Oncology
  • Transplantation Medicine

Background:

  • Optimal surgical strategies for hepatocellular carcinoma (HCC) remain debated.
  • Accurate assessment of liver functional reserve and future liver remnant volume is crucial for safe liver resection.
  • Current algorithms for HCC surgical management exhibit limitations, leading to geographical disparities in treatment approaches.

Conclusions:

  • Refined algorithms incorporating liver reserve and remnant volume are needed for HCC surgical decision-making.
  • A balanced approach to liver transplantation (LT) for HCC is essential, considering both patient-specific outcomes and the broader impact on transplant waiting lists.
  • Further research is warranted to develop standardized, equitable criteria for HCC treatment stratification.