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Updated: Mar 9, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Liquid-capped encoded microcapsules for multiplex assays.

Younghoon Song¹, Yunjin Jeong¹, Taehong Kwon¹

¹Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 151-742, Republic of Korea. skwon@snu.ac.kr and Department of Electrical and Computer Science, Seoul National University, Seoul 151-742, Republic of Korea.

|December 21, 2016

Summary

This summary is machine-generated.

This study introduces a novel liquid-capped encoded microcapsule for multiplex assays, overcoming droplet microfluidics limitations. This technology enables efficient handling of diverse analytes in various liquid formats for broad applications.

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Last Updated: Mar 9, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

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Published on: October 8, 2021

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Area of Science:

Biotechnology
Microfluidics
Assay Development

Background:

Droplet microfluidics offers advantages for single-analyte handling but struggles with high-throughput multiplex assays.
Existing methods face challenges in managing numerous distinct analytes simultaneously, limiting multiplexing capabilities.

Purpose of the Study:

To develop a novel microcapsule system for efficient, high-throughput multiplex assays.
To enable precise handling and identification of diverse liquid samples within microscale formats.

Main Methods:

Development of "liquid-capped encoded microcapsules" with graphical encoding for identification.
Encapsulation of millions of nanoliter-scale liquids within microcapsules.
Self-assembly of encoded microcapsules in microwells for streamlined processing.

Main Results:

Demonstrated graphical encoding for accurate identification of randomly assembled microcapsules.
Successfully arrayed various liquid drops without repeated dispensing, evaporation, or cross-contamination.
Validated the technology across diverse liquid-phase assays, including enzyme inhibitor screening, virus transduction, and drug-induced apoptosis tests.

Conclusions:

The liquid-capped encoded microcapsule system provides a versatile platform for various solution-phase assays.
This technology significantly enhances multiplexing capabilities and liquid handling efficiency in microfluidic applications.
The developed method offers a robust solution for complex biological and chemical analyses.