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(Pro)renin and (pro)renin receptor expression during kidney development in neonates
Tomomasa Terada1, Maki Urushihara2, Takahiko Saijo1
1Department of Pediatrics, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto-cho 3-18-15, Tokushima, 770-8503, Japan.
European Journal of Pediatrics
|December 21, 2016
Summary
The (pro)renin receptor ((P)RR) is crucial for human prenatal kidney development. Higher levels of (P)RR and its soluble form were found in preterm neonates, suggesting a role in fetal kidney maturation.
Area of Science:
- Nephrology
- Developmental Biology
- Endocrinology
Background:
- The renin-angiotensin system (RAS) is vital for blood pressure regulation and has roles in pediatric renal diseases.
- Renal RAS activation is critical for kidney development during gestation.
- The function of the (pro)renin receptor ((P)RR) in human renal development requires further elucidation.
Purpose of the Study:
- To investigate the role of (P)RR in human prenatal kidney development.
- To measure plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in neonates.
- To assess (P)RR expression in human kidney tissues.
Main Methods:
- Collected cord blood and neonatal kidney tissue samples from 57 preterm and 67 full-term neonates.
- Quantified plasma (pro)renin and s(P)RR using enzyme-linked immunosorbent assays.
- Performed immunohistochemical analysis to evaluate renal (P)RR expression.
Main Results:
- Plasma (pro)renin and s(P)RR levels were significantly higher in preterm neonates compared to full-term neonates.
- These elevated levels in preterm neonates diminished by four weeks after birth.
- Plasma (pro)renin and s(P)RR levels in cord blood showed an inverse correlation with gestational age.
- Immunohistochemistry revealed stronger renal (P)RR expression in neonates than in tissues with minor glomerular abnormalities.
Conclusions:
- The (pro)renin receptor ((P)RR) likely plays a significant role in human prenatal kidney development.
- Elevated (P)RR and s(P)RR in preterm neonates suggest its involvement in fetal kidney maturation.
- (P)RR expression is higher in developing neonatal kidneys compared to kidneys with minor abnormalities.
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