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Related Experiment Video

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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Structural Insights into Sigma1 Function.

¹Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Seeley G. Mudd Building, 250 Longwood Ave., Boston, MA, 02115, USA. Andrew_Kruse@hms.harvard.edu.

Handbook of Experimental Pharmacology

|December 21, 2016

Summary

This summary is machine-generated.

The sigma-1 receptor, a transmembrane protein, has had its molecular structure revealed through recent crystallographic studies. This breakthrough provides a framework for understanding its function in diseases like neurodegeneration and cancer.

Keywords:

Crystal structure Ligand binding Oligomer Sigma-1 receptor Sigma1 X-ray crystallography

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Area of Science:

Molecular Biology
Structural Biology
Neuroscience

Background:

The sigma-1 receptor is an enigmatic transmembrane protein involved in various biological processes.
Its molecular architecture has remained largely unclear despite extensive research.

Purpose of the Study:

To elucidate the molecular architecture of the sigma-1 receptor.
To provide a high-resolution structural view of the sigma-1 receptor.

Main Methods:

Oligomerization studies of the sigma-1 receptor.
High-resolution crystallographic analysis of the sigma-1 receptor structure.

Main Results:

Recent crystallographic studies have provided the first high-resolution molecular structure of the sigma-1 receptor.
The sigma-1 receptor has been established as an oligomer.
These structural insights offer a framework for interpreting mutagenesis data and ligand interactions.

Conclusions:

The structural era of sigma-1 receptor research is beginning.
New discoveries and reevaluation of existing data are anticipated.
Understanding the molecular basis of sigma-1 receptor function and interactions is now feasible.