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Online Hemodiafiltration Reduces Bisphenol A Levels.

Borja Quiroga1, Ricardo J Bosch2, Ruth A Fiallos1

  • 1Nephrology Unit, Hospital Universitario de Guadalajara, Guadalajara, Spain.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|December 21, 2016
PubMed
Summary

Online hemodiafiltration (OL-HDF) effectively reduces levels of the uremic toxin Bisphenol A (BPA) in patients undergoing dialysis. This study shows OL-HDF is a useful treatment for lowering BPA accumulation in chronic kidney disease patients.

Keywords:
Bisphenol AHemodialysisOnline hemodiafiltrationUremic toxins

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Area of Science:

  • Nephrology
  • Toxicology
  • Biochemistry

Background:

  • Uremic toxins contribute to morbidity and mortality in dialysis patients.
  • Bisphenol A (BPA) is a toxin that accumulates in patients with chronic kidney disease.

Purpose of the Study:

  • To evaluate the effectiveness of online hemodiafiltration (OL-HDF) in reducing Bisphenol A (BPA) levels.
  • To compare BPA reduction during OL-HDF versus high-flux hemodialysis (HF-HD).

Main Methods:

  • A paired study involving 30 stable hemodialysis patients.
  • Patients were switched between HF-HD and OL-HDF for 3-week periods.
  • Bisphenol A levels were measured using ELISA and HPLC.

Main Results:

  • A weak but significant correlation was found between HPLC and ELISA BPA measurements.
  • BPA levels significantly decreased during the OL-HDF period (P=0.002).
  • BPA levels remained stable during the HF-HD period.

Conclusions:

  • Online hemodiafiltration (OL-HDF) is effective in reducing Bisphenol A levels in dialysis patients.
  • OL-HDF offers a potential therapeutic strategy for managing BPA accumulation in chronic kidney disease.