Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural and biochemical analyses of a novel bacterial dual specificity phosphatase from Candidatus Chlorohelix allophototropha.

Journal of microbiology (Seoul, Korea)·2026
Same author

Blood-based gene signatures associated with therapeutic response to anti-TNF therapy in rheumatoid arthritis: a combined meta-analytical and machine learning approach.

EULAR rheumatology open·2026
Same author

Crystal structure of Bcl-2 from lymphocystis disease virus 2 in complex with the BH3 domain of zebrafish BaxA.

Journal of microbiology (Seoul, Korea)·2026
Same author

Deep Learning-Based Segmentation of Fetal Anatomical Structures in the First Trimester.

Prenatal diagnosis·2026
Same author

MG53, a Regenerative Myokine Linking Skeletal Muscle to Cardiac Repair.

Biomolecules·2026
Same author

Risk of Parkinson's disease in patients with schizophrenia: Impact of antipsychotic medication use.

PloS one·2026

Related Experiment Video

Updated: Mar 9, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

12.9K

Hydrogel Functionalized Janus Membrane for Skin Regeneration.

Young-Hyeon An1, Seung Jung Yu2, In Seon Kim1

  • 1School of Chemical and Biological Engineering, Seoul National University, Seoul, 152-742, Republic of Korea.

Advanced Healthcare Materials
|December 21, 2016
PubMed
Summary

A novel Janus membrane hydrogel wound dressing was developed. This innovative biomaterial promotes wound healing by retaining moisture and preventing fluid leakage.

Keywords:
hydrogel immobilizationinitiated chemical vapor depositionprotein deliverywound dressingwound healing

More Related Videos

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

4.9K
Engineering a Bilayered Hydrogel to Control ASC Differentiation
07:48

Engineering a Bilayered Hydrogel to Control ASC Differentiation

Published on: May 25, 2012

14.6K

Related Experiment Videos

Last Updated: Mar 9, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

12.9K
Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

4.9K
Engineering a Bilayered Hydrogel to Control ASC Differentiation
07:48

Engineering a Bilayered Hydrogel to Control ASC Differentiation

Published on: May 25, 2012

14.6K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Advanced wound dressings are crucial for effective healing.
  • Current dressings often struggle with moisture balance and infection control.
  • Janus membranes offer unique surface properties for tailored applications.

Purpose of the Study:

  • To develop and evaluate a hydrogel-functionalized Janus membrane as a wound dressing biomaterial.
  • To investigate the membrane's capacity for moisture retention, exudate control, and wound healing enhancement.
  • To create a multifunctional wound dressing with antibacterial and air-permeable properties.

Main Methods:

  • Fabrication of a Janus membrane by coating a polyester membrane with poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl methacrylate) (PHFDMA).
  • Modification of one side of the PHFDMA-coated membrane to create carboxylic acid residues.
  • Functionalization of the membrane with a gelatin methacrylate-based hydrogel.
  • Evaluation of the functionalized Janus membrane on a full-thickness dorsal skin defect model in rats.

Main Results:

  • The PHFDMA coating provided antibacterial properties, air permeation, and water repellency.
  • The functionalized hydrogel side ensured moisture retention within the wound.
  • The Janus membrane effectively prevented exudate leakage and enhanced wound healing rates.
  • Significant epidermal layer thickening was observed in treated wounds.

Conclusions:

  • A multifunctional Janus membrane with a hydrophobic outer surface and an immobilized hydrogel inner surface was successfully fabricated.
  • This Janus membrane hydrogel represents an innovative strategy for advanced wound healing applications.
  • The biomaterial demonstrated superior performance in moisture management, infection prevention, and accelerated tissue regeneration.