Related Experiment Video
Updated: Mar 9, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Developmental Coordination Disorder Plus Oculomotor and Visuospatial Impairment as Neurodevelopmental Heralds of
Michele Poletti1, Eva Gebhardt2, Andrea Raballo3
11. Department of Mental Health and Pathological Addiction, Child and Adolescent Psychiatry, Azienda Sanitaria Locale of Reggio Emilia, Italy.
Insights
Research is shifting focus to the premorbid period for early psychosis detection. A case study highlights how developmental disorders in children may indicate psychosis proneness.
Area of Science:
- Child and Adolescent Psychiatry
- Neurodevelopmental Disorders
- Psychosis Research
Background:
- Clinical interest in early psychosis detection is growing, with a focus shifting towards the premorbid period.
- The neurodevelopmental hypothesis of schizophrenia provides a framework for understanding early signs of vulnerability.
- Early detection efforts are increasingly targeting subtle, unspecific premorbid symptoms present from infancy and childhood.
Purpose of the Study:
- To explore the connection between early neurodevelopmental disorders and psychosis proneness in childhood.
- To illustrate the potential for child-adolescent mental health services in early psychosis detection.
- To present a clinical vignette highlighting these intertwined concepts.
Main Methods:
- Case study presentation.
- Clinical vignette analysis.
- Review of neurodevelopmental and psychosis proneness literature.
Main Results:
- The presented case involves a child with severe Developmental Coordination Disorder and Attenuated Psychosis Syndrome.
- The vignette demonstrates the complex interplay between early developmental issues and psychosis risk.
- Childhood mental health services are identified as a key setting for early detection.
Conclusions:
- Early identification of neurodevelopmental disorders may be crucial for predicting psychosis risk.
- Intervention during the premorbid period, even in early childhood, holds promise for preventing severe psychopathology.
- A developmental perspective is essential for understanding and addressing psychosis proneness from its earliest manifestations.
Abstract:
Aiming at preventing transitions to more severe psychopathology and boosted by the availability of operational criteria to identify help-seeking subjects at increased risk for psychosis, research into the early prodromal phases of psychosis is attracting a growing clinical interest. Furthermore, the focus of early detection is gradually shifting from prodromal syndromes to the premorbid period. Although mainly driven by clinical-pragatic aims, such a shift is coherent with the neurodevelopmental hypothesis of schizophrenia that might offer a unifying, developmentally informed conceptual framework for early detection. Psychotic experiences, indeed, while overtly manifested in adolescence/early-adulthood, are often antedated by subtle expressions of biological vulnerability already presenting in the early years of life and indexing a putatively altered neurodevelopmental process. Concretely, unspecific premorbid symptoms that may be present since infancy and childhood may lead to early clinical consultancy in child-adolescent mental health services, which could be considered the primary clinical setting to implement early detection. We herewith present a clinical vignette of a child with severe Developmental Coordination Disorder presenting an Attenuated Psychosis Syndrome. The vignette illustrates the intertwining between possible early neurodevelopmental disorders and clinical psychosis proneness in childhood.
Related Concept Videos
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Oppositional Defiant Disorder
Diagnostic Criteria and...
Psychological and Sociocultural Causes of Schizophrenia
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Conduct Disorder

