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DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlers

Andrew W Lee1, Emilia Jordanov2, Florence Boisnard3

  • 1a Merck & Co., Inc. , Kenilworth , NJ , USA.

Expert Review of Vaccines
|December 21, 2016
PubMed

Insights

A new hexavalent vaccine combining diphtheria, tetanus, pertussis, hepatitis B, H influenzae type b, and polio was found safe and effective in infants. This combination vaccine simplifies immunization schedules and may improve vaccination rates.

Area of Science:

  • Pediatric Vaccinology
  • Infectious Disease Prevention

Background:

  • Combination vaccines simplify childhood immunization schedules and reduce the number of injections.
  • Currently, only 5-valent DTaP-based vaccines are licensed in the U.S.

Purpose of the Study:

  • To describe a new hexavalent combination vaccine (DTaP5-IPV-Hib-HepB).
  • To evaluate the immunogenicity and safety of this new vaccine in infants.

Main Methods:

  • Infants received the DTaP5-IPV-Hib-HepB vaccine on various schedules, including a 2, 4, and 6-month schedule.
  • Antibody responses to each component vaccine were measured.

Main Results:

  • The hexavalent vaccine induced antibody responses similar to individual component vaccines.
  • The vaccine was found to be safe, with higher rates of mild fever but no significant safety concerns.
  • The vaccine is expected to protect against diphtheria, tetanus, pertussis, hepatitis B, H. influenzae type b, and polio.

Conclusions:

  • The DTaP5-IPV-Hib-HepB hexavalent vaccine demonstrates favorable immunogenicity and safety profiles in infants.
  • Incorporation into the U.S. immunization schedule could enhance vaccination coverage and timeliness.
  • This vaccine would expand the range of combination vaccines available in the European Union market.
Abstract

Keywords:
DiphtheriaHepatitis BHibPoliocombination vaccinehexavalentimmunogenicitypertussissafetytetanusvaccine

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