[Treatment of chronic glomerulonephritis with cytostatics]

A retrospective analysis was made of the efficacy of oral treatment with cytostatics (azathioprin, batriden, cyclophosphamide) in 109 patients with chronic glomerulonephritis (CGN) (with a known morphologic appearance in 94 patients) and with excessive doses of cyclophosphamide i. v. in 32 patients with CGN depending on the nephritis standing, its clinical pattern and morphologic variant. The best results were recorded with nephritis lasting up to 2 years in patients suffering from the nephrotic pattern of CGN or at the stage of the nephrotic syndrome formation in patients with latent CGN, in membranoproliferative, membranous and membranocapillary versions of CGN, during pulse therapy, and in patients with focal segmental glomerulohyalinosis. No remissions were observed in mixed CGN. The experimental data are also provided concerning the influence of a single oral cyclophosphamide administration on the morphologic signs of nephritis in GBA and C57BL mice.