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Updated: Mar 9, 2026
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Obesity as an independent risk factor for group B streptococcal colonization
Mitchell D Alvareza1, Akila Subramaniam1, Ying Tang1
1a Division of Maternal-Fetal Medicine , University of Alabama at Birmingham, Center for Women's Reproductive Health , Birmingham , AL , USA.
Objective:
Approximately 25% of women are colonized with group B streptococcus (GBS). We assessed whether body mass index (BMI) is an independent risk factor for GBS colonization.
Study Design:
We performed a retrospective cohort study using a previously collected database of women who delivered singleton gestations at term. Individual patient medical record review was undertaken to add GBS-related information to the database. Univariable logistic regression was used to assess the relationship between GBS colonization and BMI. Multivariable logistic regression was used to adjust for confounders.
Results:
A total of 2045 patients met enrollment criteria. The prevalence of GBS colonization was 29%. In the unadjusted analysis, there was a statistically significant increase in GBS colonization per unit increase in BMI (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.01-1.04). This relationship remained significant after adjusting for confounders (race, marital status, payer, chronic hypertension, concomitant genital infections) (OR 1.01, 95% CI 1.00-1.03; p = 0.04). By BMI category, there were no differences in antibiotic susceptibilities or mode of ascertainment of GBS colonization.
Conclusion:
Obesity is an independent risk factor for GBS colonization; however, this association is weak.
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