Related Experiment Video

Updated: Mar 9, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.3K

Structural and Functional Correlates of Myocardial T1 Mapping in 321 Patients With Hypertrophic Cardiomyopathy

Linda C Chu1, Celia P Corona-Villalobos, Marc K Halushka

  • 1From the *Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine and Departments of †Pathology and ‡Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD; §Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; and ∥Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD.

Journal of Computer Assisted Tomography
|December 21, 2016
PubMed

Insights

Late gadolinium enhancement more strongly correlates with hypertrophic cardiomyopathy (HCM) phenotypes than T1 mapping. This cardiac MRI technique helps assess disease expression in HCM patients.

Area of Science:

  • Cardiovascular Imaging
  • Cardiac MRI
  • Cardiomyopathy Research

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex genetic heart disease.
  • Assessing the phenotypic expression of HCM is crucial for patient management.
  • Cardiac magnetic resonance (CMR) techniques like T1 mapping and late gadolinium enhancement (LGE) offer insights into myocardial tissue characteristics.

Purpose of the Study:

  • To evaluate the structural and functional correlates of T1 mapping in a large cohort of HCM patients.
  • To compare the correlation of T1 mapping with LGE in reflecting HCM phenotypes.
  • To determine the utility of T1 ratio and LGE in assessing cardiac structure and function in HCM.

Main Methods:

  • Retrospective analysis of 321 HCM patients undergoing CMR.
  • Quantification of left ventricular (LV) volume, function, LGE, and T1 time.
  • Calculation of T1 ratio and correlation analysis with LGE% and clinical parameters.

Main Results:

  • LGE showed a stronger correlation with LV mass index (r=0.41) than T1 ratio (r=-0.17).
  • Both LGE% and T1 ratio correlated with ejection fraction, but in opposite directions.
  • E/e' correlated with LGE% but not with T1 ratio, suggesting differential tissue characterization.

Conclusions:

  • Late gadolinium enhancement is a more robust marker for the phenotypic expression of HCM compared to T1 ratio.
  • CMR-derived T1 mapping and LGE provide complementary information in HCM assessment.
  • Further research may elucidate the specific roles of T1 mapping in HCM.
Abstract

More Related Videos

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

7.4K
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.4K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
602
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.1K