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Familial Creutzfeldt-Jakob Disease Cluster Among an African American Family

Matthew G Johnson¹, Kristy K Bradley, Rebecca L Coffman

¹Epidemic Intelligence Service (Dr Johnson), Acute Disease Service (Ms Coffman), and Office of the State Epidemiologist (Dr Bradley), Oklahoma State Department of Health, Oklahoma City, Oklahoma; and National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (Dr Belay).

Journal of Public Health Management and Practice : JPHMP

|December 21, 2016

Abstract:

Familial Creutzfeldt-Jakob disease (fCJD) results from inheritance of mutations in the prion protein gene. Confirming fCJD diagnosis is essential for informing persons of their potential hereditary risk and for genetic counseling to support personal decisions for genetic testing and family planning. We describe a case of fCJD that was linked to a large cluster of African Americans with fCJD identified through a public health investigation, including 8 confirmed cases and 13 suspected cases involving 7 generations in 1 family. Genetic counseling is an important component of fCJD management for families coping with genetic prion diseases.

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