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Severe excessive daytime sleepiness induced by hydroxyurea.

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Hydroxyurea therapy can unexpectedly cause severe daytime sleepiness. Stopping the medication resolved the excessive daytime sleepiness, indicating a direct link.

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Area of Science:

  • Pharmacology
  • Neurology
  • Sleep Medicine

Background:

  • Excessive daytime sleepiness (EDS) is a known side effect of various medications, often linked to central nervous system depression.
  • However, idiosyncratic reactions can also manifest as unexplained sleepiness.

Observation:

  • This study details a case of severe subjective and objective EDS in a patient undergoing hydroxyurea therapy.
  • The patient exhibited significant sleepiness not attributable to other common causes.

Findings:

  • Hydroxyurea was identified as the causative agent for the unexpected and severe EDS.
  • Diagnostic evaluations including polysomnography and multiple sleep latency tests ruled out other potential causes of sleepiness.

Implications:

  • This finding highlights hydroxyurea as a potential cause of severe EDS, requiring clinical vigilance.
  • Withdrawal of hydroxyurea led to a favorable outcome, suggesting a reversible drug-induced effect.