Related Experiment Video
Updated: Mar 9, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
How to manage hypertension with atherosclerotic renal artery stenosis?
Jean-Baptiste Ricco1, Romain Belmonte2, Guilio Illuminati3
1Department of Vascular Surgery, University Hospital of Poitiers, Poitiers, France - jeanbaptistericco@gmail.com.
Abstract:
The management of atherosclerotic renal artery stenosis (ARAS) in patients with hypertension has been the topic of great controversy. Major contemporary clinical trials such as the Cardiovascular Outcomes for Renal Artery lesions (CORAL) and Angioplasty and Stenting for Renal Atherosclerotic lesions (ASTRAL) have failed to show significant benefit of revascularization over medical management in controlling blood pressure and preserving renal function. We present here the implications and limitations of these trials and formulate recommendations for management of ARAS.
Related Concept Videos
Atherosclerosis III: Management
Antihypertensive Drugs: Direct Renin Inhibitors
Atherosclerosis IV: Nursing Management
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Hypertension V: Nursing Management
Hypertension IV: Drug Therapy and Lifestyle Modifications

