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Linezolid: a promising option in the treatment of Gram-positives

Abed Zahedi Bialvaei1, Mohammad Rahbar2, Mehdi Yousefi3

  • 1Department of Microbiology, Iran University of Medical Sciences, Tehran, Iran.

The Journal of Antimicrobial Chemotherapy
|December 22, 2016
PubMed

Insights

Linezolid is a crucial antibiotic for Gram-positive bacterial infections. Monitoring for linezolid resistance is essential to ensure its continued effectiveness in treating serious infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Linezolid is an oxazolidinone antimicrobial effective against Gram-positive bacteria, including VRE and MRSA.
  • It functions by uniquely inhibiting bacterial protein synthesis.
  • Increasing antibiotic resistance globally necessitates careful management of effective agents like linezolid.

Purpose of the Study:

  • To review and optimize the clinical application of linezolid.
  • To highlight the importance of susceptibility testing for linezolid.

Main Methods:

  • Literature review on linezolid's efficacy and resistance patterns.
  • Analysis of current clinical guidelines and resistance trends.

Main Results:

  • Linezolid remains effective with low resistance rates (<1.0%) in many Gram-positive pathogens.
  • Emerging resistance warrants increased vigilance and routine susceptibility testing.

Conclusions:

  • Linezolid is vital for treating infections caused by resistant Gram-positive bacteria.
  • Routine susceptibility testing and careful therapeutic consideration are recommended to preserve linezolid's efficacy.

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