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Published on: April 28, 2013
Tendinitis--a common complication after renal transplantation
M S Murison1, I Eardley, M Slapak
1Wessex Regional Transplant Unit, St. Mary's Hospital, Portsmouth, United Kingdom.
Transplantation
|October 1, 1989
Summary
Tendinitis is common after renal transplantation, affecting 20% of patients. Steroid use, especially cumulative doses, is linked to tendinitis and Achilles tendon rupture in transplant recipients.
Area of Science:
- Nephrology
- Orthopedics
- Immunology
Background:
- Renal transplantation is a life-saving procedure for end-stage renal disease.
- Patients undergoing renal transplantation often receive immunosuppressive therapy, including corticosteroids.
- The long-term effects of immunosuppression on musculoskeletal health are not fully understood.
Purpose of the Study:
- To investigate the incidence and risk factors of tendinitis in patients with functional renal allografts.
- To assess the association between corticosteroid therapy and tendinitis in renal transplant recipients.
- To evaluate potential correlations with HLA matching and dialysis duration.
Main Methods:
- A cohort of 170 patients with functioning renal allografts were assessed for tendinitis symptoms and signs.
- Patients were evaluated for Achilles and Supraspinatus tendon involvement.
- Data on steroid use, HLA matching, dialysis history, and biochemical markers were collected.
Main Results:
- Tendinitis was observed in 20% (34/170) of renal transplant recipients.
- A significant correlation was found between cumulative steroid dose and tendinitis symptoms.
- Four patients experienced spontaneous Achilles tendon rupture; all had received steroids.
- HLA matching and time on dialysis were also related to tendinitis incidence.
Conclusions:
- Tendinitis is a common complication following renal transplantation.
- Corticosteroid therapy, particularly cumulative dosage, is a significant risk factor for tendinitis in this population.
- Further research is warranted to elucidate the mechanisms and optimize management strategies.
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