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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

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MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

Chen Li1, Kai Zhang1, Jing Chen1

  • 1Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, PR China.

Oncotarget
|December 22, 2016
PubMed

Insights

MicroRNAs and forkhead box transcription factors are key in cancer. Understanding their axis offers new therapeutic strategies for cancer treatment, despite existing challenges.

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • MicroRNAs (miRNAs) are crucial regulators in both tumor suppressive and oncogenic pathways in human cancers.
  • Forkhead box (FOX) transcription factors are involved in critical cellular processes like cell cycle, metabolism, metastasis, and angiogenesis, promoting tumor initiation and progression.

Purpose of the Study:

  • To review the current understanding of the interplay between microRNAs and forkhead box transcription factors.
  • To elucidate the roles of the microRNA-forkhead box axis in various diseases, particularly in tumor initiation and progression.
  • To discuss the challenges associated with targeting this axis for cancer therapy.

Main Methods:

  • Literature review synthesizing current knowledge on microRNA and forkhead box transcription factor interactions.
  • Analysis of published data on the involvement of these molecules in cancer pathways.
  • Discussion of technical challenges in therapeutic applications.

Main Results:

  • MicroRNAs and forkhead box transcription factors form a complex regulatory network influencing cancer development.
  • The microRNA-forkhead box axis plays significant roles in tumor initiation, progression, and metastasis.
  • Identification of specific microRNA-forkhead box interactions provides insights into oncogenic and tumor-suppressive mechanisms.

Conclusions:

  • The intricate relationship between microRNAs and forkhead box transcription factors is central to cancer biology.
  • Targeting the microRNA-forkhead box axis holds promise for novel cancer therapeutics.
  • Overcoming technical hurdles is essential for the successful clinical translation of these findings.
Keywords:
cancerforkhead box transcription factormicroRNApost-transcriptional regulation

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