Serotonin Syndrome With Fluoxetine: Two Case Reports
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Updated: Mar 9, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
Dipen Dineshkumar Patel1, David Galarneau2
1The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
Background:
Serotonin syndrome is a rare but serious complication of treatment with serotonergic agents. In its severe manifestations, death can ensue. Early recognition and aggressive management are crucial to mitigating the syndrome. Often the presentation can be subtle and easy to miss.
Case Reports:
We present 2 cases of serotonin syndrome seen in the psychiatric consultation service of a busy academic hospital. Both patients had favorable outcomes because of early recognition and aggressive management.
Conclusion:
Physicians should carefully consider and rule out the clinical diagnosis of serotonin syndrome when presented with an agitated or confused patient who is taking serotonergic agents.
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