Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

13.6K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
13.6K
Olfaction01:25

Olfaction

49.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
49.4K
Tactile and Chemical Senses01:27

Tactile and Chemical Senses

1.2K
Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.
1.2K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

13.6K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
13.6K
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

4.7K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urine-Based Noninvasive Detection of Prostate Cancer Using Human Olfactory Receptor-Embedded Nanodiscs.

ACS sensors·2026
Same author

Indole-3-propionic Acid Is an Endogenous Agonist of TAS2R38.

Journal of agricultural and food chemistry·2026
Same author

Nanodiscs embedded with μ-opioid receptors as decoy receptors to reverse opioid overdose.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Nondestructive methodology with discerning fruit freshness biomarker compounds using olfactory receptor nanodisc-loaded graphene transistors.

Biosensors & bioelectronics·2025
Same author

Combinatorial Pattern Response of Bioelectronic Nose for the Detection of Real Nerve Agents.

ACS sensors·2024
Same author

Umami taste receptor suppresses cancer cachexia by regulating skeletal muscle atrophy <i>in vivo</i> and <i>in vitro</i>.

Nutrition research and practice·2024

Related Experiment Video

Updated: Mar 9, 2026

Fruit Volatile Analysis Using an Electronic Nose
11:02

Fruit Volatile Analysis Using an Electronic Nose

Published on: March 30, 2012

22.4K

Bioelectronic nose and its application to smell visualization.

Hwi Jin Ko1, Tai Hyun Park2

  • 1Bio-MAX Institute, Seoul, 151-742 Republic of Korea.

Journal of Biological Engineering
|December 22, 2016
PubMed
Summary

Researchers are developing advanced bioelectronic noses to objectively visualize smell. These devices combine biological materials and nanomaterials for enhanced sensitivity and selectivity in odor detection, paving the way for future smell visualization technologies.

Keywords:
Bioelectronic noseEngineered olfactory cellsNano-biotechnologyNanovesiclesOdorantOlfactory receptorOptoelectronic noseSmell visualization

More Related Videos

Electroantennography-based Bio-hybrid Odor-detecting Drone using Silkmoth Antennae for Odor Source Localization
06:00

Electroantennography-based Bio-hybrid Odor-detecting Drone using Silkmoth Antennae for Odor Source Localization

Published on: August 27, 2021

6.2K
Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

7.5K

Related Experiment Videos

Last Updated: Mar 9, 2026

Fruit Volatile Analysis Using an Electronic Nose
11:02

Fruit Volatile Analysis Using an Electronic Nose

Published on: March 30, 2012

22.4K
Electroantennography-based Bio-hybrid Odor-detecting Drone using Silkmoth Antennae for Odor Source Localization
06:00

Electroantennography-based Bio-hybrid Odor-detecting Drone using Silkmoth Antennae for Odor Source Localization

Published on: August 27, 2021

6.2K
Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

7.5K

Area of Science:

  • Biotechnology and Sensor Technology
  • Olfactory Science
  • Nanomaterials in Biosensing

Background:

  • Human olfaction is subjective, necessitating objective methods for smell detection and visualization.
  • Existing technologies like GC-MS, electronic noses, and optoelectronic noses have limitations in sensitivity and scope.
  • Mimicking the human olfactory system has led to engineered olfactory cells and bioelectronic noses.

Approach:

  • Bioelectronic noses integrate biological materials (primary transducer) for selectivity and nanomaterials (secondary transducer) for sensitivity.
  • Utilizing human olfactory receptors or nanovesicles from engineered cells enhances odor detection capabilities.
  • Development focuses on multi-channel array-sensing systems and signal processing for visual output.

Key Points:

  • Bioelectronic noses offer potential for detecting a wide range of odors by mimicking the human olfactory system.
  • Engineered olfactory cells can express various human olfactory receptors, improving sensor versatility.
  • Overcoming current limitations requires integrated multi-channel systems and advanced signal-to-image conversion techniques.

Conclusions:

  • Bioelectronic noses represent a promising tool for objective smell visualization.
  • Further technological advancements in sensor integration and signal processing are crucial for realizing practical applications.
  • The future of smell visualization relies on the successful development of these sophisticated bioelectronic systems.